Respiratory disease is a leading health issue for dairy calves, particularly between 20 to 45 days of age, when they are most vulnerable. Early detection is essential for effective treatment, as symptoms such as reduced milk intake, elevated breathing rates, and nasal discharge can often appear subtly at first. This resource delves into identifying key symptoms, understanding common pathogens, and implementing preventive measures through nutrition, environment, and vaccinations. Armed with this knowledge, farmers can better protect their calves from respiratory disease.